Please print and give your veterinarian a copy of the current research being done at Purdue University Vet School under the direction of Dr. Larry Glickman. They are half way through this 5 year study of Vaccine-Induced Autoimmunity in the dog and there is already some evidence of thyroid, heart, bone disease (HOD like symptoms) due to vaccines. Many Dane, Beagle and Golden Retriever breeders have known for some time there is a problem with vaccines. Soon science will prove what we have known for some time. 

If you veterinarian has any doubt or questions (s)he can contact Dr. Glickman at Purdue to see that this is indeed a valid study. Below is a copy of Dr. LaRosa's statement regarding the study. He is a Trustee for the Hayward Genetics Foundation, they are funding in part this research. 

Dr. Linda Arndt

Blackwatch Great Dane Kennels



A Possible Etiology of Autoimmune Diseases

By William R. La Rosa, M.D. Trustee- Hayward Foundation 

The Hayward Foundation is dedicated to research and eradication of human genetic diseases. 

There is much anecdotal hearsay about the safety of vaccines in dogs as well as in humans. 

The Vaccine Safety Committee recently emphasized the need for more definitive research on possible adverse effects during the development of new vaccines and vaccine combinations. 

(National Academy Press, Washington D.C. 1994). 

When a dog vaccine safety issue was brought to our attention by Laura Kiaulenas, a prominent Harlequin Great Dane breeder, and after reading articles by Jean Dodds DVM, we decided to fund a study to prove or disprove the supposi-tion of multiple diseases, acute and chronic, caused by vaccination. 

If indeed, many breeders are correct, then is the dog a canary sentinel, and are human similarly being affected, and if so can we identify the dog or human who is genetically susceptible to these reactions ? 

We were fortunate that prominent and respected researchers, Drs. Larry T. Glickman, Harm HogenEsch, Juan I. Azona-Olivera, J. Catherine Scott-Montcrieff, and Paul W. Snyder of Purdue University, School of Veterinary Medicine, agreed to undertake the study.

 The results are enlightening and they are enthusiastically working on the second phase, a study of longer duration. 

They presented a paper to the International Veterinary Vaccines and Diagnostics Conference, July 27 - 31, 1997, in Madison, Wisconsin, hosted by the University of Wisconsin and at the International Canine Immunogenetics and Immunologcal Diseases Conference at the School of Veterinary Medicine at UC Davis, July 31-98 - August 2, 1998.                                    

These proceedings have been published in "Advances in Veterinary Science and Comparative Medicine." Another manuscript "Induced Serum Auto antibodies in Young Beagles", has been submitted to a human immunology journal "Clinical Immunology and Immmunopathology." 

Their study was based on the increasing concern among veterinarians and breeders that current vaccination protocols adversely affect the health of dogs. 

This concern has largely been based on an overwhelming anecdotal and  circumstantial evidence. 

They studied the effects of routinely used vaccination protocol on the immune and endocrine systems of Beagles. One control group was not vaccinated and the other group was vaccinated with a commercial multivalent vaccine at 8, 10, 12, 16, and 20 weeks of age and with a rabies vaccine at 16 weeks of age. 

A definition of Autoimmune disease is now necessary. 

In dogs as well as humans, the body sometimes forms antibodies against itself (self antigens) which can lead to diseases of the pancreas (diabetes), thyroid (Hashimoto's Disease), collagen and fibronectin (Scleroderma, Lupus), cardiolipin (Cardiomyopathy), etc.


VACCINE SAFETY A Possible Etiology of Autoimmune Diseases

By William R. La Rosa, M.D. (Trustee) 

The body literally attacks itself to cause the autoimmune disease. The vaccinated group developed significant levels of autoantibodies against fibronectin, laminin, DNA, albumin, Cytochrome C, transferrin, cardiolipin, collagen. The re-sponses varied among individual animals, probably reflecting genetic differences. 

The clinical significance of those autoantibodies remains to be determined,but speculation must be that something in the vaccines is one of the etiologies (in the genetically susceptible dog) of such diseases as Cardiomyopathy, Lupus Erythematosus, Glomerulonephritis, etc. 

I apologise for using these technical terms but this is a complex study and adds validity to the report. 

Autoimmune diseases are quite common in dogs as well as in humans, but much easier to study in dogs, especially since various breeds have genetic susceptibility or predisposition.

The high prevalence of autoimmune disease in specific breeds makes it easier to search for the genetic markers. 

Humans are much more diverse and therefore more difficult to study. 

We hope that many Breed Associations and the AKC Foundation will join us in expanding these studies with the needed research funds. Longer term studies are needed to determine the clinical importance of vaccine-induced autoantibodies and to identify markers of genetic susceptability. 

These are truly remarkable results.                                                                           

The next step is to study the development of safer vaccines, or possibly modify the recommended dosages, and the timing of vaccinations. Many vaccines, including a vaccine for use in humans, contain fibronectin. This appears to be a common contaminant. 

Other antigens will be studied. 

A general theme of the Conference was that vaccine immunity lasts longer than the manufacturer claims; rabies is probably effective for at least 3 years and we are probably over-vaccinating our dogs. Even the vaccine industry tells you that there is never 100% protection. Therefore disease is seen even in vaccinated groups. 

In Europe, vaccines are prohibited once the disease is eliminated because the fear of reversion to virulence of the modified live virus.

 Autoimmune diseases in dogs are clinically similar to those in humans. We hope that Veterinary and Medical Schools will continue and expand these preliminary research studies.

Our companion dogs are crashing all around us and maybe we are now finding one of the sources of the problems.

 It has been so easy to point fingers at breeders but they may not be entirely at fault. 

Let us continue this important research to help our future generations of dogs and possibly children. 

Yes, indiscriminate breeding can genetically predispose the dog but is the trigger mechanism indiscriminate vaccinations ?

My personal interpretation of the above information in brief is:

1 )These studies appear to support the conclusions of some breeders  that multiple vaccinations may be harmful to dogs.  Be cautious and keep current in the scientific literature.

2 ) Current vaccines induce autoantibodies. Contaminants may be part of the problem.

3 ) We need to research and explain the mechanism.  Does it alter the  DNA causing genetic abnormality or is the susceptible gene already in place ? Can we find the genetic marker to avoid the adverse reaction of vaccination?

4 ) The dog is a good model for study because different breeds already have susceptibility to specific diseases and genetic markers will be easier to find than in other diverse animals (and humans).

5 ) What is the solution or cure, and especially how is this applicable to humans.

6 ) Most current vaccines are effective in preventing disease, but they may be administered more frequently than is actually required.          

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